Thursday, November 18, 2010
Monday, November 15, 2010
When I began my career in antimicrobial resistance at the Centers for Disease Control and Prevention (CDC), cephalosporin-resistant Enterobacteriaceae and methicillin-resistant Staphylococcus aureus were the focus of attention . In a few short years, bacterial pathogens have continued to outwit us by changing their genetic make-up enough to survive nearly all antibiotics that might be considered for treatment.
In the past 10 years, carbapenems have been the “drugs of last resort” for Enterobacteriaceae. However, today we have identified carbapenem-resistant Enterobacteriaceae (CRE), which carry an enzyme called the Klebsiella pneumoniae carbapenemase (KPC), in at least 35 states and globally. Most recently, CRE with new mechanisms of resistance (called NDM-1 and VIM) were also identified in the United States.
Now is the time for action. Antibiotics are a shared resource – and becoming a scarce resource. Appropriate use of existing antibiotics can limit the spread of antibiotic resistance, preserving antibiotics for the future.
On November 15-18, 2010, CDC and our partners will observe Get Smart About Antibiotics Week, in an effort to focus attention on improving antibiotic use as a key effort to reduce antibiotic resistance. The U.S. observance will coincide with the European and Canadian antibiotic awareness days, November 18, 2010. In conjunction with Get Smart Week 2010, CDC will unveil its new Get Smart for Healthcare campaign focused on improving antibiotic use in hospitals and long-term care facilities. Improving antibiotic use in in-patient settings can improve cure rates and reduce Clostridium difficile.
Together, we can address this global resistance threat. By leveraging our collective resources towards preserving these vital therapies for the future, we can protect patients and save lives.
Antibiotics were long considered “miracle drugs,” capable of saving lives from bacterial infections once considered fatal. However, decades of misuse and overuse have led to the emergence of antibiotic-resistant strains of bacteria invulnerable to many of the drugs we have available today. Since 1981, APUA has promoted improved antimicrobial access and more appropriate use with the goal of “preserving the power of antibiotics”®. We accomplish our mission by conducting antimicrobial resistance research, education, and advocacy at the grassroots, national and global levels.
By extending into the blogosphere, APUA experts intend to serve as a global platform to provide insights and provoke your responses on the impact of antibiotic resistance and strategies for improving antibiotic access and use. We will feature entries from the APUA Staff and our Expert Panel, which consists of selected members of our Scientific Advisory Board, APUA chapter leaders, and other experts in this field. We encourage you to join in the discussion.
Kathleen Young, Executive Director and Stuart B. Levy, MD, President